Jeff and Anne, two close friends and co-workers in a suburban high school, are embarrassingly unlucky at love. With nothing else to lose, they hatch a plan to transform themselves over the course of a sex-and-alcohol-fueled summer into the cool, confident people they aspire to be. At first an exhilarating adventure of self-discovery, Jeff and Anne's journey turns into a laugh-out-loud experiment as they lose their identities, their dignity, and quite possibly each other.

Jennifer's thirtieth birthday party is supposed to be a special day. But what starts out as a day of celebration quickly spirals into a most ill-fated day Jennifer wishes she could forget, in this ensemble comedy set entirely in a kitchen.

Ryden Malby has planned her academic life since she was in high-school to get a college scholarship; now she has just graduated in English and in her master plan she expects to get a job as assistant editor in the publishing house Happerman & Browning, in Los Angeles. Her platonic best friend is Adam Davis that has a crush on her and is frequently close to her. However, her arrogant classmate Jessica Bard gets the position and Ryden is forced to return home in the suburb to live with her optimistic father Walter that wants to do everything by himself; her careful mother Carmella that administrates the short resources of her family; her eccentric grandmother Maureen; and her weird little brother Hunter that wishes to race in a boxcar derby. Ryden unsuccessfully seeks a job position and feels frustrated but is emotionally supported by Adam. When Walter accidentally runs over the cat of his next-door neighbor David Santiago with Ryden's car...

In Los Angeles, Andy Conners works in Fearless Records selecting new talents. Andy is in love and engaged to Lauren Baker for one year but he is unable to satisfy Lauren in bed. Further, he has never told Lauren that he loves her. Andy tells his problem to his best friend Layne Wilson and they research how to satisfy Lauren with an orgasm. Meanwhile Lauren is promoted in her company but she needs to be transferred to Chicago. When her colleague Daniel Meltzer comes to Los Angeles to convince Lauren to move to Chicago, they discover that they had been friends in the childhoods. Andy misunderstands the relationship between Daniel and Lauren and believes that she is cheating on him. Will Andy lose Lauren to Daniel?

In New York, when the shy and lonely project manager of a design firm Matt Saunders meets Jenny Johnson in the subway, he invites her to date and have dinner with him. Jenny immediately falls in love for him, they have sex and she discloses her true identity to him, telling that she is the powerful superhero G-Girl. After meeting his co-worker and friend Hannah Lewis, the needy Jenny becomes jealous, controlling and manipulative, and Matt follows the advice of his best friend Vaughn Haige and dumps her, breaking her heart. Jenny turns Matt's life into hell, while he has a romance with Hannah. However, the archenemy of G-Girl and former high school sweetheart of Jenny, Professor Bedlam, proposes Matt to lure Jenny to strip her superpowers.